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Involvement of Akt in Mitomycin C and Its Analog Triggered Cytotoxicity in MCF-7 and K562 cancer cells
Mitomycin C (MC) is a well-known DNA alkylating agent. MC analog, 10-decarbamoyl mitomycin C (DMC), unlike MC, has stronger effects on cancer with p53 mutation. We previously demonstrated that MC/DMC could activate p21(WAF1/CIP1) in MCF-7 (p53-proficient) and K562 (p53-deficient) cells in a p53-inde...
Shranjeno v:
| izdano v: | Chem Biol Drug Des |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6251731/ https://ncbi.nlm.nih.gov/pubmed/30091208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13374 |
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