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Involvement of Akt in Mitomycin C and Its Analog Triggered Cytotoxicity in MCF-7 and K562 cancer cells

Mitomycin C (MC) is a well-known DNA alkylating agent. MC analog, 10-decarbamoyl mitomycin C (DMC), unlike MC, has stronger effects on cancer with p53 mutation. We previously demonstrated that MC/DMC could activate p21(WAF1/CIP1) in MCF-7 (p53-proficient) and K562 (p53-deficient) cells in a p53-inde...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Biol Drug Des
Main Authors: Cheng, Shu-Yuan, Vargas, Anayatzinc, Lee, Ji-Young, Clement, Cristina C., Champeil, Elise
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251731/
https://ncbi.nlm.nih.gov/pubmed/30091208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13374
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