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Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21(WAF1/CIP1) activation
Mitomycin C (MC), a commonly used anticancer drug, induces DNA damage via DNA alkylation. Decarbamoyl mitomycin C (DMC), another mitomycin lacking the carbamate at C10, generates similar lesions as MC. Interstrand cross-links (ICLs) are believed to be the lesions primarily responsible for the cytoto...
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| Gepubliceerd in: | Int J Oncol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
D.A. Spandidos
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5063421/ https://ncbi.nlm.nih.gov/pubmed/27666201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2016.3703 |
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