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Suppression of p53 and p21(CIP1/WAF1) reduces arsenite-induced aneuploidy
Aneuploidy and extensive chromosomal rearrangements are common in human tumors. The role of DNA damage response proteins p53 and p21(CIP1/WAF1) in aneugenesis and clastogenesis was investigated in telomerase immortalized diploid human fibroblasts using siRNA suppression of p53 and p21(CIP1/WAF1). Ce...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825144/ https://ncbi.nlm.nih.gov/pubmed/20000476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900353v |
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