Suppression of p53 and p21(CIP1/WAF1) reduces arsenite-induced aneuploidy

Aneuploidy and extensive chromosomal rearrangements are common in human tumors. The role of DNA damage response proteins p53 and p21(CIP1/WAF1) in aneugenesis and clastogenesis was investigated in telomerase immortalized diploid human fibroblasts using siRNA suppression of p53 and p21(CIP1/WAF1). Ce...

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Autori principali: Salazar, Ana María, Miller, Heather L., McNeely, Samuel C., Sordo, Monserrat, Ostrosky-Wegman, Patricia, States, J. Christopher
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825144/
https://ncbi.nlm.nih.gov/pubmed/20000476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900353v
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