p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6

p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence. Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cance...

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Главные авторы: Phalke, Sameer, Mzoughi, Slim, Bezzi, Marco, Jennifer, Nancy, Mok, Wei Chuen, Low, Diana H. P., Thike, Aye Aye, Kuznetsov, Vladimir A., Tan, Puay Hoon, Voorhoeve, P. Mathijs, Guccione, Ernesto
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Gene Regulation, Chromatin and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479215/
https://ncbi.nlm.nih.gov/pubmed/22987071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks858
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