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p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence. Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cance...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479215/ https://ncbi.nlm.nih.gov/pubmed/22987071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks858 |
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