Epigenetic control of a VDR-governed feed-forward loop that regulates p21((waf1/cip1)) expression and function in non-malignant prostate cells

In non-malignant RWPE-1 prostate epithelial cells signaling by the nuclear receptor Vitamin D Receptor (VDR, NR1I1) induces cell cycle arrest through targets including CDKN1A (encodes p21((waf1/cip1))). VDR dynamically induced individual histone modification patterns at three VDR binding sites (R1,...

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Detalhes bibliográficos
Main Authors: Thorne, James L., Maguire, Orla, Doig, Craig L., Battaglia, Sebastiano, Fehr, Leah, Sucheston, Lara E., Heinaniemi, Merja, O’Neill, Laura P., McCabe, Christopher J., Turner, Bryan M., Carlberg, Carsten, Campbell, Moray J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064804/
https://ncbi.nlm.nih.gov/pubmed/21088000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq875
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