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Sequence-Dependent Diastereospecific and Diastereodivergent Crosslinking of DNA by Decarbamoylmitomycin C

Mitomycin C (MC), a potent antitumor drug, and decarbamoylmitomycin C (DMC), a derivative lacking the carbamoyl group, form highly cytotoxic DNA interstrand crosslinks. The major interstrand crosslink formed by DMC is the C1” epimer of the major crosslink formed by MC. The molecular basis for the st...

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Bibliografiska uppgifter
I publikationen:Chemistry
Huvudupphovsmän: Aguilar, William, Paz, Manuel M., Vargas, Anayatzinc, Clement, Cristina C., Cheng, Shu-Yuan, Champeil, Elise
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046179/
https://ncbi.nlm.nih.gov/pubmed/29504661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201705771
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