Synthesis of Mitomycin C and Decarbamoylmitomycin C N(6) deoxyadenosine-adducts

Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede DNA replication and, thereby, block cancer cells pr...

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Bibliografiske detaljer
Udgivet i:Bioorg Chem
Main Authors: Zheng, Maggie, Hwang, Seokjin, Snyder, Timothy, Aquilina, Jake, Proni, Gloria, Paz, Manuel M., Pradhan, Padmanava, Cheng, Shu-Yuan, Champeil, Elise
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936608/
https://ncbi.nlm.nih.gov/pubmed/31539740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2019.103280
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