Synthesis of Mitomycin C and Decarbamoylmitomycin C N(6) deoxyadenosine-adducts

Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede DNA replication and, thereby, block cancer cells pr...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Bioorg Chem
Auteurs principaux: Zheng, Maggie, Hwang, Seokjin, Snyder, Timothy, Aquilina, Jake, Proni, Gloria, Paz, Manuel M., Pradhan, Padmanava, Cheng, Shu-Yuan, Champeil, Elise
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936608/
https://ncbi.nlm.nih.gov/pubmed/31539740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2019.103280
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires