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Mutation S115T in IMP-Type Metallo-β-Lactamases Compensates for Decreased Expression Levels Caused by Mutation S119G

(1) Background: Metallo-β-lactamases (MBLs) have raised concerns due to their ability to inactivate carbapenems and newer generation cephalosporins and the absence of clinically available MBL inhibitors. Their genes are often transferred horizontally, and the number of MBL variants has grown exponen...

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Dettagli Bibliografici
Pubblicato in:Biomolecules
Autori principali: Zhang, Charles J., Faheem, Mohammad, Dang, Paulie, Morris, Monica N., Kumar, Pooja, Oelschlaeger, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920813/
https://ncbi.nlm.nih.gov/pubmed/31718049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9110724
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