Role of Synonymous Mutations in the Evolution of TEM β-Lactamase Genes

Nonsynonymous mutations are well documented in TEM β-lactamases. The resulting amino acid changes often alter the conferred phenotype from broad spectrum (2b) conferred by TEM-1 to extended spectrum (2be), inhibitor resistant (2br), or both extended spectrum and inhibitor resistant (2ber). The encod...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Faheem, Mohammad, Zhang, Charles J., Morris, Monica N., Pleiss, Juergen, Oelschlaeger, Peter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315918/
https://ncbi.nlm.nih.gov/pubmed/33820762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00018-21
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