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Impact of remote mutations on metallo-β-lactamase substrate specificity: Implications for the evolution of antibiotic resistance
Metallo-β-lactamases have raised concerns due to their ability to hydrolyze a broad spectrum of β-lactam antibiotics. The G262S point mutation distinguishing the metallo-β-lactamase IMP-1 from IMP-6 has no effect on the hydrolysis of the drugs cephalothin and cefotaxime, but significantly improves c...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279297/ https://ncbi.nlm.nih.gov/pubmed/15722450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041093405 |
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