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Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-β-lactamase
Numerous X-ray crystal structures of the metallo-β-lactamase from Bacteroides fragilis and related organisms show a β-hairpin loop immediately adjacent to the active-site zinc atom(s). Both crystallographic and NMR information show that the end of this β-hairpin loop, which contains a solvent expose...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley-Blackwell
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323931/ https://ncbi.nlm.nih.gov/pubmed/12824483 |
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