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Understanding the determinants of substrate specificity in IMP family metallo-β-lactamases: The importance of residue 262
In Gram-negative bacteria, resistance to β-lactam antibacterials is largely due to β-lactamases and is a growing public health threat. One of the most concerning β-lactamases to evolve in bacteria are the Class B enzymes, the metallo-β-lactamases (MBLs). To date, penams and cephems resistant to hydr...
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| Publicado en: | Protein Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4287004/ https://ncbi.nlm.nih.gov/pubmed/25131397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2530 |
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