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Understanding the determinants of substrate specificity in IMP family metallo-β-lactamases: The importance of residue 262

In Gram-negative bacteria, resistance to β-lactam antibacterials is largely due to β-lactamases and is a growing public health threat. One of the most concerning β-lactamases to evolve in bacteria are the Class B enzymes, the metallo-β-lactamases (MBLs). To date, penams and cephems resistant to hydr...

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Bibliografski detalji
Izdano u:Protein Sci
Glavni autori: Pegg, Kevin M, Liu, Eleanor M, George, Alex C, LaCuran, Alecander E, Bethel, Christopher R, Bonomo, Robert A, Oelschlaeger, Peter
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287004/
https://ncbi.nlm.nih.gov/pubmed/25131397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2530
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