Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by impaired lysosomal acidification remain poorly understood. We show here that inhibition of lysosomal acidi...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Yambire, King Faisal, Rostosky, Christine, Watanabe, Takashi, Pacheu-Grau, David, Torres-Odio, Sylvia, Sanchez-Guerrero, Angela, Senderovich, Ola, Meyron-Holtz, Esther G, Milosevic, Ira, Frahm, Jens, West, A Phillip, Raimundo, Nuno
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917501/
https://ncbi.nlm.nih.gov/pubmed/31793879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51031
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