Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by impaired lysosomal acidification remain poorly understood. We show here that inhibition of lysosomal acidi...

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Udgivet i:eLife
Main Authors: Yambire, King Faisal, Rostosky, Christine, Watanabe, Takashi, Pacheu-Grau, David, Torres-Odio, Sylvia, Sanchez-Guerrero, Angela, Senderovich, Ola, Meyron-Holtz, Esther G, Milosevic, Ira, Frahm, Jens, West, A Phillip, Raimundo, Nuno
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917501/
https://ncbi.nlm.nih.gov/pubmed/31793879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51031
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