Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by impaired lysosomal acidification remain poorly understood. We show here that inhibition of lysosomal acidi...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Yambire, King Faisal, Rostosky, Christine, Watanabe, Takashi, Pacheu-Grau, David, Torres-Odio, Sylvia, Sanchez-Guerrero, Angela, Senderovich, Ola, Meyron-Holtz, Esther G, Milosevic, Ira, Frahm, Jens, West, A Phillip, Raimundo, Nuno
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6917501/
https://ncbi.nlm.nih.gov/pubmed/31793879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51031
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