Optogenetic Acidification of Synaptic Vesicles and Lysosomes

Acidification is required for the function of many intracellular organelles, but methods to acutely manipulate their intraluminal pH have not been available. Here we present a targeting strategy to selectively express the light-driven proton pump Arch3 on synaptic vesicles. Our new tool, pHoenix, ca...

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Detaylı Bibliyografya
Yayımlandı:Nat Neurosci
Asıl Yazarlar: Rost, Benjamin R., Schneider, Franziska, Grauel, M. Katharina, Wozny, Christian, Bentz, Claudia, Blessing, Anja, Rosenmund, Tanja, Jentsch, Thomas J., Schmitz, Dietmar, Hegemann, Peter, Rosenmund, Christian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869830/
https://ncbi.nlm.nih.gov/pubmed/26551543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4161
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