Optogenetic Acidification of Synaptic Vesicles and Lysosomes

Acidification is required for the function of many intracellular organelles, but methods to acutely manipulate their intraluminal pH have not been available. Here we present a targeting strategy to selectively express the light-driven proton pump Arch3 on synaptic vesicles. Our new tool, pHoenix, ca...

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Publicat a:Nat Neurosci
Autors principals: Rost, Benjamin R., Schneider, Franziska, Grauel, M. Katharina, Wozny, Christian, Bentz, Claudia, Blessing, Anja, Rosenmund, Tanja, Jentsch, Thomas J., Schmitz, Dietmar, Hegemann, Peter, Rosenmund, Christian
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869830/
https://ncbi.nlm.nih.gov/pubmed/26551543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4161
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