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Optogenetic Acidification of Synaptic Vesicles and Lysosomes
Acidification is required for the function of many intracellular organelles, but methods to acutely manipulate their intraluminal pH have not been available. Here we present a targeting strategy to selectively express the light-driven proton pump Arch3 on synaptic vesicles. Our new tool, pHoenix, ca...
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| Publicado en: | Nat Neurosci |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4869830/ https://ncbi.nlm.nih.gov/pubmed/26551543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4161 |
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