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Novel benzimidazole phosphonates as potential inhibitors Of protein prenylation
Benzimidazole carboxyphosphonates and bisphosphonates have been prepared and evaluated for their activity as inhibitors of protein prenylation or isoprenoid biosynthesis. The nature of the phosphonate head group was found to dictate enzyme specificity. The lead carboxyphosphonate inhibits geranylger...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911684/ https://ncbi.nlm.nih.gov/pubmed/31699606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126757 |
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