Novel benzimidazole phosphonates as potential inhibitors Of protein prenylation

Benzimidazole carboxyphosphonates and bisphosphonates have been prepared and evaluated for their activity as inhibitors of protein prenylation or isoprenoid biosynthesis. The nature of the phosphonate head group was found to dictate enzyme specificity. The lead carboxyphosphonate inhibits geranylger...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Bhuiyan, Nazmul H., Varney, Michelle L., Wiemer, David F., Holstein, Sarah A.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911684/
https://ncbi.nlm.nih.gov/pubmed/31699606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126757
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