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Prodrugs of phosphonates and phosphates: crossing the membrane barrier
A substantial portion of metabolism involves transformation of phosphate esters, including pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and steroids, and phosphorylated proteins. Because the natural substrates bear one or more negative charges, drugs that target t...
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| Publicat a: | Top Curr Chem |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4774048/ https://ncbi.nlm.nih.gov/pubmed/25391982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/128_2014_561 |
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