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Prodrugs of phosphonates and phosphates: crossing the membrane barrier
A substantial portion of metabolism involves transformation of phosphate esters, including pathways leading to nucleotides and oligonucleotides, carbohydrates, isoprenoids and steroids, and phosphorylated proteins. Because the natural substrates bear one or more negative charges, drugs that target t...
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| Publicado no: | Top Curr Chem |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4774048/ https://ncbi.nlm.nih.gov/pubmed/25391982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/128_2014_561 |
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