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Stability and Efficiency of Mixed Aryl Phosphonate Prodrugs
A set phosphonate prodrugs of a butyrophilin ligand was synthesized and evaluated for plasma stability and cellular activity. The mixed aryl acyloxy esters were prepared either via a standard sequence through the phosphonic acid chloride, or through the more recently reported, and more facile, trifl...
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| Veröffentlicht in: | ChemMedChem |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6726502/ https://ncbi.nlm.nih.gov/pubmed/31226236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900344 |
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