Phosphinophosphonates and their tris-pivaloyloxymethyl prodrugs reveal a negatively cooperative butyrophilin activation mechanism

Butyrophilin 3A1 (BTN3A1) binds small phosphorous-containing molecules, which initiates transmembrane signaling and activates butyrophilin-responsive cells. We synthesized several phosphinophosphonates and their corresponding tris-pivaloyloxymethyl prodrugs and examined their effects on BTN3A1. An a...

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Pubblicato in:J Med Chem
Autori principali: Shippy, Rebekah R., Lin, Xiaochen, Agabiti, Sherry S., Li, Jin, Zangari, Brendan M., Foust, Benjamin J., Poe, Michael M., Hsiao, Chia-Hung Christine, Vinogradova, Olga, Wiemer, David F., Wiemer, Andrew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754923/
https://ncbi.nlm.nih.gov/pubmed/28218845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00965
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