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Synthesis and Bioactivity of the Alanyl Phosphonamidate Stereoisomers Derived from a Butyrophilin Ligand

[Image: see text] Aryloxy phosphonamidate derivatives of a butyrophilin 3A1 ligand are stimulants of Vγ9 Vδ2 T cells. However, when bonded to an aryl ester and an amine, the phosphorus is stereogenic, and past compounds were studied as racemates. To determine the impact of stereochemistry on the act...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Lentini, Nicholas A., Hsiao, Chia-Hung Christine, Crull, George B., Wiemer, Andrew J., Wiemer, David F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2019
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746094/
https://ncbi.nlm.nih.gov/pubmed/31531198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00153
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