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Synthesis and Bioactivity of the Alanyl Phosphonamidate Stereoisomers Derived from a Butyrophilin Ligand

[Image: see text] Aryloxy phosphonamidate derivatives of a butyrophilin 3A1 ligand are stimulants of Vγ9 Vδ2 T cells. However, when bonded to an aryl ester and an amine, the phosphorus is stereogenic, and past compounds were studied as racemates. To determine the impact of stereochemistry on the act...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Lentini, Nicholas A., Hsiao, Chia-Hung Christine, Crull, George B., Wiemer, Andrew J., Wiemer, David F.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2019
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746094/
https://ncbi.nlm.nih.gov/pubmed/31531198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00153
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