Synthesis and Metabolism of BTN3A1 Ligands: Studies on Modifications of the Allylic Alcohol

[Image: see text] (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) and its phosphonate analogs are potent phosphoantigens. HMBPP contains an (E)-allylic alcohol which interacts with the molecular target BTN3A1 giving an antigenic signal to activate Vγ9Vδ2 T cells. As probes of BTN3A1 function,...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Lentini, Nicholas A., Schroeder, Chloe M., Harmon, Nyema M., Huang, Xueting, Schladetsch, Megan A., Foust, Benjamin J., Poe, Michael M., Hsiao, Chia-Hung Christine, Wiemer, Andrew J., Wiemer, David F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812676/
https://ncbi.nlm.nih.gov/pubmed/33488975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00586
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