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Phosphonamidate prodrugs of a butyrophilin ligand display plasma stability and potent Vγ9Vδ2 T cell stimulation
Small organophosphorus compounds stimulate Vγ9Vδ2 T cells if they serve as ligands of butyrophilin 3A1. Because the most potent natural ligand is (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), which is the last intermediate in bacterial biosynthesis of isoprenoids that is not found in mammal...
Guardat en:
| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6703555/ https://ncbi.nlm.nih.gov/pubmed/30199251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00655 |
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