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Metabolic Efficacy of Phosphate Prodrugs and the Remdesivir Paradigm

[Image: see text] Drugs that contain phosphates (and phosphonates or phosphinates) have intrinsic absorption issues and are therefore often delivered in prodrug forms to promote their uptake. Effective prodrug forms distribute their payload to the site of the intended target and release it efficient...

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Détails bibliographiques
Publié dans:ACS Pharmacol Transl Sci
Auteur principal: Wiemer, Andrew J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409933/
https://ncbi.nlm.nih.gov/pubmed/32821882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00076
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