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ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors
The enzyme geranylgeranyl diphosphate synthase (GGDPS) is a potential therapeutic target for multiple myeloma. Malignant plasma cells produce and secrete large amounts of monoclonal protein, and inhibition of GGDPS results in disruption of protein geranylgeranylation which in turn impairs intracellu...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6936606/ https://ncbi.nlm.nih.gov/pubmed/31474482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126633 |
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