ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

The enzyme geranylgeranyl diphosphate synthase (GGDPS) is a potential therapeutic target for multiple myeloma. Malignant plasma cells produce and secrete large amounts of monoclonal protein, and inhibition of GGDPS results in disruption of protein geranylgeranylation which in turn impairs intracellu...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Bhuiyan, Nazmul H., Varney, Michelle L., Bhattacharya, Deep S., Payne, William M., Mohs, Aaron M., Holstein, Sarah A., Wiemer, David F.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936606/
https://ncbi.nlm.nih.gov/pubmed/31474482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126633
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