ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

The enzyme geranylgeranyl diphosphate synthase (GGDPS) is a potential therapeutic target for multiple myeloma. Malignant plasma cells produce and secrete large amounts of monoclonal protein, and inhibition of GGDPS results in disruption of protein geranylgeranylation which in turn impairs intracellu...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Bhuiyan, Nazmul H., Varney, Michelle L., Bhattacharya, Deep S., Payne, William M., Mohs, Aaron M., Holstein, Sarah A., Wiemer, David F.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936606/
https://ncbi.nlm.nih.gov/pubmed/31474482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126633
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