In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution

The enzyme geranylgeranyl diphosphate synthase (GGDPS) synthesizes the 20-carbon isoprenoid geranylgeranyl pyrophosphate, which is used in geranylgeranylation reactions. We have demonstrated that GGDPS inhibitors in multiple myeloma (MM) cells disrupt Rab geranylgeranylation, leading to inhibition o...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Haney, Staci L., Chhonker, Yashpal S., Varney, Michelle L., Talmon, Geoffrey, Smith, Lynette M., Murry, Daryl J., Holstein, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795743/
https://ncbi.nlm.nih.gov/pubmed/31420526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.258624
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