Llwytho...

Quantitative Determination of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor using LC- MS/MS: Derivatization and Application

An isomeric mixture of homogeranyl/homoneryl triazole bisphosphonates (VSW1198) has previously been shown to be a potent inhibitor of geranylgeranyl diphosphate (GGDP) synthase (GGDPS) and of therapeutic interest for the treatment of multiple myeloma. We have developed and validated a selective and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharm Biomed Anal
Prif Awduron: Chhonker, Yashpal S., Haney, Staci L., Matthiesen, Robert A., Wiemer, David F., Holstein, Sarah A., Murry, Daryl J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5857472/
https://ncbi.nlm.nih.gov/pubmed/29455093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2018.02.010
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