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Preclinical Investigation of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor
Geranylgeranyl diphosphate synthase (GGDPS) is the enzyme in the isoprenoid biosynthesis pathway that catalyzes the synthesis of the 20-carbon isoprenoid GGPP, which serves as the isoprenoid donor for protein geranylgeranylation reactions. Rab proteins mediate vesicle trafficking within the cell and...
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| Udgivet i: | Invest New Drugs |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6119657/ https://ncbi.nlm.nih.gov/pubmed/29497895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-018-0571-3 |
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