Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Rab proteins play an essential role in regulating intracellular membrane trafficking processes. Rab activity is dependent upon geranylgeranylation, a post-translational modification that involves the addition of 20-carbon isoprenoid chains via the enzyme geranylgeranyl transferase (GGTase) II. We ha...

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Publicado no:Oncogene
Main Authors: Haney, Staci L., Varney, Michelle L., Chhonker, Yashpal S., Shin, Simon, Mehla, Kamiya, Crawford, Ayrianne J., Smith, Heather Jensen, Smith, Lynette M., Murry, Daryl J., Hollingsworth, Michael A., Holstein, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597278/
https://ncbi.nlm.nih.gov/pubmed/30918331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0794-6
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