Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Rab proteins play an essential role in regulating intracellular membrane trafficking processes. Rab activity is dependent upon geranylgeranylation, a post-translational modification that involves the addition of 20-carbon isoprenoid chains via the enzyme geranylgeranyl transferase (GGTase) II. We ha...

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Pubblicato in:Oncogene
Autori principali: Haney, Staci L., Varney, Michelle L., Chhonker, Yashpal S., Shin, Simon, Mehla, Kamiya, Crawford, Ayrianne J., Smith, Heather Jensen, Smith, Lynette M., Murry, Daryl J., Hollingsworth, Michael A., Holstein, Sarah A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597278/
https://ncbi.nlm.nih.gov/pubmed/30918331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0794-6
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