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Quantitative Determination of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor using LC- MS/MS: Derivatization and Application
An isomeric mixture of homogeranyl/homoneryl triazole bisphosphonates (VSW1198) has previously been shown to be a potent inhibitor of geranylgeranyl diphosphate (GGDP) synthase (GGDPS) and of therapeutic interest for the treatment of multiple myeloma. We have developed and validated a selective and...
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| Publicat a: | J Pharm Biomed Anal |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5857472/ https://ncbi.nlm.nih.gov/pubmed/29455093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2018.02.010 |
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