Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase

The isoprenoid donor for protein geranylgeranylation reactions, geranylgeranyl diphosphate (GGDP), is the product of the enzyme GGDP synthase (GGDPS) that condenses farnesyl diphosphate (FDP) and isopentenyl pyrophosphate. GGDPS inhibition is of interest from a therapeutic perspective for multiple m...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Allen, Cheryl, Kortagere, Sandhya, Tong, Huaxiang, Matthiesen, Robert A., Metzger, Joseph I., Wiemer, David F., Holstein, Sarah A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325083/
https://ncbi.nlm.nih.gov/pubmed/28057800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.107326
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