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α-Methylation Enhances the Potency of Isoprenoid Triazole Bisphosphonates as Geranylgeranyl Diphosphate Synthase Inhibitors

Disruption of protein geranylgeranylation via inhibition of geranylgeranyl diphosphate synthase (GGDPS) represents a novel therapeutic strategy for a variety of malignancies, especially those characterized by excessive protein secretion such as multiple myeloma. Our work has demonstrated that some i...

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Pubblicato in:Bioorg Med Chem
Autori principali: Matthiesen, Robert A., Varney, Michelle L., Xu, Pauline C., Rier, Alex S., Wiemer, David F., Holstein, Sarah A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752576/
https://ncbi.nlm.nih.gov/pubmed/29248353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.10.023
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