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Novel benzimidazole phosphonates as potential inhibitors Of protein prenylation
Benzimidazole carboxyphosphonates and bisphosphonates have been prepared and evaluated for their activity as inhibitors of protein prenylation or isoprenoid biosynthesis. The nature of the phosphonate head group was found to dictate enzyme specificity. The lead carboxyphosphonate inhibits geranylger...
Gorde:
| Argitaratua izan da: | Bioorg Med Chem Lett |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6911684/ https://ncbi.nlm.nih.gov/pubmed/31699606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126757 |
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