High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

Repeat-associated non-AUG (RAN) translation is a noncanonical translation initiation event that occurs at nucleotide-repeat expansion mutations that are associated with several neurodegenerative diseases, including fragile X–associated tremor ataxia syndrome (FXTAS), ALS, and frontotemporal dementia...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Green, Katelyn M., Sheth, Udit J., Flores, Brittany N., Wright, Shannon E., Sutter, Alexandra B., Kearse, Michael G., Barmada, Sami J., Ivanova, Magdalena I., Todd, Peter K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901296/
https://ncbi.nlm.nih.gov/pubmed/31649034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009951
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