RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings may inform therapeutic development. Here we analyze...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Green, Katelyn M., Glineburg, M. Rebecca, Kearse, Michael G., Flores, Brittany N., Linsalata, Alexander E., Fedak, Stephen J., Goldstrohm, Aaron C., Barmada, Sami J., Todd, Peter K.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722904/
https://ncbi.nlm.nih.gov/pubmed/29222490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02200-0
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