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The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD
An intronic hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This repeat is thought to elicit toxicity through RNA mediated protein sequestration and repeat-associated non-AUG (RAN) translation of dipeptide...
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出版年: | Acta Neuropathol Commun |
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主要な著者: | , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
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BioMed Central
2020
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7401224/ https://ncbi.nlm.nih.gov/pubmed/32753055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01002-8 |
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