The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

An intronic hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This repeat is thought to elicit toxicity through RNA mediated protein sequestration and repeat-associated non-AUG (RAN) translation of dipeptide...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: He, Fang, Flores, Brittany N., Krans, Amy, Frazer, Michelle, Natla, Sam, Niraula, Sarjina, Adefioye, Olamide, Barmada, Sami J., Todd, Peter K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401224/
https://ncbi.nlm.nih.gov/pubmed/32753055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01002-8
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi