The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

An intronic hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This repeat is thought to elicit toxicity through RNA mediated protein sequestration and repeat-associated non-AUG (RAN) translation of dipeptide...

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Publicado en:Acta Neuropathol Commun
Autores principales: He, Fang, Flores, Brittany N., Krans, Amy, Frazer, Michelle, Natla, Sam, Niraula, Sarjina, Adefioye, Olamide, Barmada, Sami J., Todd, Peter K.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401224/
https://ncbi.nlm.nih.gov/pubmed/32753055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01002-8
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