An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration

Por Flores, Brittany N., Li, Xingli, Malik, Ahmed M., Martinez, Jose, Beg, Asim A., Barmada, Sami J.
Publicado no Cell Rep (2019)

The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

Por He, Fang, Flores, Brittany N., Krans, Amy, Frazer, Michelle, Natla, Sam, Niraula, Sarjina, Adefioye, Olamide, Barmada, Sami J., Todd, Peter K.
Publicado no Acta Neuropathol Commun (2020)

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity

Por Flores, Brittany N., Dulchavsky, Mark E., Krans, Amy, Sawaya, Michael R., Paulson, Henry L., Todd, Peter K., Barmada, Sami J., Ivanova, Magdalena I.
Publicado no PLoS One (2016)

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

Por Green, Katelyn M., Glineburg, M. Rebecca, Kearse, Michael G., Flores, Brittany N., Linsalata, Alexander E., Fedak, Stephen J., Goldstrohm, Aaron C., Barmada, Sami J., Todd, Peter K.
Publicado no Nat Commun (2017)

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

Por Green, Katelyn M., Sheth, Udit J., Flores, Brittany N., Wright, Shannon E., Sutter, Alexandra B., Kearse, Michael G., Barmada, Sami J., Ivanova, Magdalena I., Todd, Peter K.
Publicado no J Biol Chem (2019)

DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation

Por Linsalata, Alexander E, He, Fang, Malik, Ahmed M, Glineburg, Mary Rebecca, Green, Katelyn M, Natla, Sam, Flores, Brittany N, Krans, Amy, Archbold, Hilary C, Fedak, Stephen J, Barmada, Sami J, Todd, Peter K
Publicado no EMBO Rep (2019)

A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis

Por Rodriguez, Caitlin M., Wright, Shannon E., Kearse, Michael G., Haenfler, Jill M., Flores, Brittany N., Liu, Yu, Ifrim, Marius F., Glineburg, Mary R., Krans, Amy, Jafar-Nejad, Paymaan, Sutton, Michael A., Bassell, Gary J., Parent, Jack M., Rigo, Frank, Barmada, Sami J., Todd, Peter K.
Publicado no Nat Neurosci (2020)

Exome sequence analysis suggests genetic burden contributes to phenotypic variability and complex neuropathy

Por Gonzaga-Jauregui, Claudia, Harel, Tamar, Gambin, Tomasz, Kousi, Maria, Griffin, Laurie B., Francescatto, Ludmila, Ozes, Burcak, Karaca, Ender, Jhangiani, Shalini, Bainbridge, Matthew N., Lawson, Kim S., Pehlivan, Davut, Okamoto, Yuji, Withers, Marjorie, Mancias, Pedro, Slavotinek, Anne, Reitnauer, Pamela J, Goksungur, Meryem T., Shy, Michael, Crawford, Thomas O., Koenig, Michel, Willer, Jason, Flores, Brittany N., Pediaditrakis, Igor, Us, Onder, Wiszniewski, Wojciech, Parman, Yesim, Antonellis, Anthony, Muzny, Donna M., Katsanis, Nicholas, Battaloglu, Esra, Boerwinkle, Eric, Gibbs, Richard A., Lupski, James R.
Publicado no Cell Rep (2015)