Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity

Hexanucleotide repeat expansions in C9orf72 are the most common inherited cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expansions elicit toxicity in part through repeat-associated non-AUG (RAN) translation of the intronic (GGGGCC)(n) sequence into dipeptide rep...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Flores, Brittany N., Dulchavsky, Mark E., Krans, Amy, Sawaya, Michael R., Paulson, Henry L., Todd, Peter K., Barmada, Sami J., Ivanova, Magdalena I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077081/
https://ncbi.nlm.nih.gov/pubmed/27776165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165084
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