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Toxic PR(n) poly-dipeptides encoded by the C9orf72 repeat expansion block nuclear import and export
The toxic proline:arginine (PR(n)) poly-dipeptide encoded by the (GGGGCC)(n) repeat expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the central channel of the nuclear pore and inhibits the movement of macromolecules into and out of the nucleus. The PR(n) poly-...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Proc Natl Acad Sci U S A |
|---|---|
| Prif Awduron: | , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
National Academy of Sciences
2017
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5320981/ https://ncbi.nlm.nih.gov/pubmed/28069952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620293114 |
| Tagiau: |
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