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Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers

Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Murray, Dylan T., Zhou, Xiaoming, Kato, Masato, Xiang, Siheng, Tycko, Robert, McKnight, Steven L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196502/
https://ncbi.nlm.nih.gov/pubmed/30279180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806174115
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