Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers

Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Murray, Dylan T., Zhou, Xiaoming, Kato, Masato, Xiang, Siheng, Tycko, Robert, McKnight, Steven L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196502/
https://ncbi.nlm.nih.gov/pubmed/30279180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806174115
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