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Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers

Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Murray, Dylan T., Zhou, Xiaoming, Kato, Masato, Xiang, Siheng, Tycko, Robert, McKnight, Steven L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196502/
https://ncbi.nlm.nih.gov/pubmed/30279180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806174115
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